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Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient

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Version 2 2020-05-18, 11:28
Version 1 2020-04-28, 09:57
journal contribution
posted on 2020-05-18, 11:28 authored by Jing Sun, Airu Zhu, Heying Li, Kui Zheng, Zhen Zhuang, Zhao Chen, Yongxia Shi, Zhaoyong Zhang, Si-bei Chen, Xuesong Liu, Jun Dai, Xiaobo Li, Shuxiang Huang, Xiaofang Huang, Ling Luo, Liyan Wen, Jianfen Zhuo, Yuming Li, Yanqun Wang, Lu Zhang, Yanjun Zhang, Fang Li, Liqiang Feng, Xinwen Chen, Nanshan Zhong, Zifeng Yang, Jicheng Huang, Jincun Zhao, Yi-min Li

SARS-CoV-2 caused a major outbreak of severe pneumonia (COVID-19) in humans. Viral RNA was detected in multiple organs in COVID-19 patients. However, infectious SARS-CoV-2 was only isolated from respiratory specimens. Here, infectious SARS-CoV-2 was successfully isolated from urine of a COVID-19 patient. The virus isolated could infect new susceptible cells and was recognized by its’ own patient sera. Appropriate precautions should be taken to avoid transmission from urine.

Funding

This study was approved by the Health Commission of Guangdong Province to use patient’s specimen for this study. This study was funded by grants from The National Key Research and Development Program of China (2018YFC1200100), National Science and Technology Major Project (2018ZX10301403), the emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology (2020YFC0841400) and Guangdong province (2020B111108001, 2018B020207013).

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    Emerging Microbes and Infections

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    Keywords

    COVID-19urinetransmissionSARS-CoV-2virus isolation

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    CC BY 4.0

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