Isolation, structural identification and biological characterization of two conopeptides from the <i>Conus pennaceus</i> venom

<p>A novel anti-mollusk conopeptide pn4c was isolated from the <i>Conus pennaceus</i> venom by repeated HPLC fractionation based on the activity against freshwater snails. The primary structure of pn4c was determined by the mass spectrometric <i>de novo</i> sequencing analysis. In addition, pn3a was isolated from the same fraction containing pn4c, as a peptide with unknown functions.</p>