Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom

Abdel-Wahab, Mohammed; Miyashita, Masahiro; Ota, Yoshiyuki; Juichi, Hironori; Okabe, Ryota; Sarhan, Moustafa; Fouda, Maged; Abdel-Rahman, Mohamed; Saber, Samy; Nakagawa, Yoshiaki

doi:10.6084/m9.figshare.5335948

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Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom

journal contribution

posted on 2017-08-23, 09:46 authored by Mohammed Abdel-Wahab, Masahiro Miyashita, Yoshiyuki Ota, Hironori Juichi, Ryota Okabe, Moustafa Sarhan, Maged Fouda, Mohamed Abdel-Rahman, Samy Saber, Yoshiaki Nakagawa

A novel anti-mollusk conopeptide pn4c was isolated from the Conus pennaceus venom by repeated HPLC fractionation based on the activity against freshwater snails. The primary structure of pn4c was determined by the mass spectrometric de novo sequencing analysis. In addition, pn3a was isolated from the same fraction containing pn4c, as a peptide with unknown functions.