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Isomer directed assembly of two Ca(II) compounds based on 5-(n-pyridyl)tetrazole-2-isopropanoic acid (n = 2, 3) and action against Hela cells

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journal contribution
posted on 09.11.2018 by Xiao Qing Gu, Guang Ming Li, Xin Zhang, Dian Yu Chen, Gao Wen Yang, Qiao Yun Li

Isomers sometimes play a fundamental role in the formation of coordination architectures. In this article, bifunctional 5-(n-pyridyl)tetrazole-2-isopropanoic acid (n = 2, 3) has been designed and prepared. Then, reactions of Ca(NO3)2·4H2O with isomeric 5-(n-pyridyl)tetrazole-2-isopropanoic acid (denoted as Hn-pytzipa, n = 2, 3) afforded mononuclear [Ca(2-pytzipa)2(H2O)4] (1) and one-dimensional [Ca(3-pytzipa)2(H2O)2]n (2), respectively. In 1, 2-pytzipa is a bidentate ligand which chelates one Ca(II) via the nitrogen atoms of the pyridine and tetrazole rings while in 2, 3-pytzipa bridges adjacent Ca(II) centers in a μ1,1,3-COO mode. PEG-5000 (poly(ethyleneglycol-5000)) coated [Ca(2-pytzipa)2(H2O)4] (1) and [Ca(3-pytzipa)2(H2O)2]n (2) nanoparticles (NPs) show toxicity towards Hela cells, but the ligands are non-toxic in nature and 2 is superior to 1. Furthermore, cell migration across a 2D artificial gap indicates that both NPs can inhibit the migration of Hela cells.


The authors acknowledge financial support from the Natural Science Foundation of Jiangsu Province (Grant No. BK2012210), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grant No. 10KJB430001) and the Opening Fund of Jiangsu Key Laboratory of Advanced Functional Materials (Grant No. 12KFJJ010).