gnpl_a_1660656_sm6775.pdf (2.4 MB)
Jatrophacine, a 4,5-seco-rhamnofolane diterpenoid with potent anti-inflammatory activity from Jatropha curcas
Version 2 2021-08-20, 11:20
Version 1 2019-09-05, 08:41
journal contribution
posted on 2019-09-05, 08:41 authored by Hu Yang, Zhao Huimin, Yang Aiping, Lv Qi, Ding Ning, Lu Tu-Lin, Hu Lihong, Xiachang WangA new diterpenoid named jatrophacine (1), with an unusual 4,5-seco- rhamnofolane skeleton, was isolated from the roots of Jatropha curcas, together with eleven known diterpenoids. The structure of the new compound was elucidated through a detailed analysis of its 1 D- and 2 D-NMR spectra. The X-ray structure of jatrophol (2) is also presented. Anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that compound 1 strongly inhibited the production of nitric oxide (IC50 = 0.53 μM).