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Jatrophacine, a 4,5-seco-rhamnofolane diterpenoid with potent anti-inflammatory activity from Jatropha curcas

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posted on 05.09.2019 by Hu Yang, Zhao Huimin, Yang Aiping, Lv Qi, Ding Ning, Lu Tu-Lin, Hu Lihong, Xiachang Wang

A new diterpenoid named jatrophacine (1), with an unusual 4,5-seco- rhamnofolane skeleton, was isolated from the roots of Jatropha curcas, together with eleven known diterpenoids. The structure of the new compound was elucidated through a detailed analysis of its 1 D- and 2 D-NMR spectra. The X-ray structure of jatrophol (2) is also presented. Anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that compound 1 strongly inhibited the production of nitric oxide (IC50 = 0.53 μM).

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This work was financially supported by the Ministry of Science and Technology of the People’s Republic of China under National Key R&D Program (2018YFC1707000, 2018YFC1707900).

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