ganp_a_1592164_sm6405.pdf (548.76 kB)
Kalshiolin A, new lignan from Kalimeris shimadai
journal contribution
posted on 2019-06-13, 11:21 authored by Guo-Kai Wang, Wen-Fang Jin, Nan Zhang, Gang Wang, Yung-Yi Cheng, Susan L. Morris-Natschke, Masuo Goto, Zhong-Yu Zhou, Jin-Song Liu, Kuo-Hsiung LeeThe Asian plant Kalimeris shimadai has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (1), and 12 known lignans (2–13). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute configuration of 1 was determined from ECD calculations. The new compound 1 was also screened for cytotoxic activity but did not show significant potency (IC50 35.9–43.3 μM) against A549, MDA-MB-231, MCF7, KB, and KB-VIN cell lines.