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MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053

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posted on 07.02.2018 by Rodney Lacret, Daniel Oves-Costales, Ignacio Pérez-Victoria, Mercedes de la Cruz, Caridad Díaz, Francisca Vicente, Olga Genilloud, Fernando Reyes

A new medermycin derivative, MDN-0171 (1), and two known structurally related compounds, medermycin (2) and antibiotic G15-F (3) were isolated from the acetone extract of culture broths of the marine-derived Streptomyces albolongus strain CA-186053. Their structures were determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). Compounds 2 and 3 accounted for the antimicrobial activity (against methicillin-resistant Staphylococcus aureus and Escherichia coli) previously detected in the crude extract of this actinomycete.

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