lsyc_a_1584675_sm6054.pdf (1.99 MB)
Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik-Fields reaction applying amides as the starting materials
Version 2 2020-02-10, 09:57
Version 1 2019-03-26, 12:34
journal contribution
posted on 2020-02-10, 09:57 authored by Anna Tripolszky, Lili Zoboki, Erika Bálint, János Kóti, György KeglevichA series of acylated α-aminophosphine oxides were synthesized by the microwave-assisted Kabachnik-Fields reaction of a series of carboxylic acid amides, formaldehyde and secondary phosphine oxides. To compensate the lower reactivity of the -NH2 reagents, they had to be used in an excess. The solvolytic condensations furnished the α-aminophosphine oxides in yields of 58-93% after purification by chromatography.