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Microwave-assisted catalyst-free synthesis of tetrasubstituted pyrroles using dialkyl acetylenedicarboxylates and monophenacylanilines

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Version 3 2016-06-22, 20:32
Version 2 2016-05-21, 07:42
Version 1 2016-04-18, 19:37
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posted on 2016-06-22, 20:32 authored by Arumugam Mariappan, Kandasamy Rajaguru, Shanmugam Muthusubramanian, Nattamai Bhuvanesh

An efficient catalyst-free microwave-assisted synthesis of tetrasubstituted pyrroles using dialkyl acetylenedicarboxylates and substituted monophenacylanilines has been developed. Axial chirality has been noticed in some N-(α-naphthyl/2-isopropylphenyl)-2,3-dicarbethoxy-4-arylpyrroles, but not with N-aryl-2,3-dicarbethoxy-4-(α-naphthyl)pyrrole.

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