Multicomponent Preparation of Quinazolinone Derivatives in the Presence of TiO₂ Nanoparticles Supported Ionic Liquids

In this study, triazoloquinazolinone and benzimidazoquinazolinone derivatives have been synthesized via a suitable and efficient procedure using one-pot multicomponent reactions of 3-amino-1,2,4-triazole or 2-aminobenzimidazole, dimedone and aromatic aldehydes in the presence of TiO₂@ILs as an efficient nanocatalyst. In the presented approach all of the products were prepared with good to excellent yields using TiO₂@ILs nanostructures. Moreover, the TiO₂ NPs were prepared using beet juice extract and functionalized with ILs based on imidazole. TiO₂@ILs nanocatalyst has been characterized by different techniques such as Fourier transforms infrared, thermogravimetric analysis, X-ray diffraction, scanning electron microscope and energy-dispersive X-ray spectroscopy. Moreover, this ionic liquid presented itself as a good protective and activator agent for nanocatalyst.