NaOH/Et3N-Promoted Stereoselective One-Pot Synthesis of α-Diazo Oxime Ethers via Diazo Transfer Reaction

Kumar Kuruba, Bharath; Shariff, Nusrathulla; Vasanthkumar, Samuel; Emmanuvel, Lourdusamy

doi:10.6084/m9.figshare.1568821.v4

lsyc_a_1085575_sm0795.pdf (1022.17 kB)

NaOH/Et₃N-Promoted Stereoselective One-Pot Synthesis of α-Diazo Oxime Ethers via Diazo Transfer Reaction

Version 4 2015-10-28, 01:12

Version 3 2015-10-28, 01:12

Version 2 2015-10-08, 17:24

Version 1 2015-10-28, 01:12

journal contribution

posted on 2015-10-28, 01:12 authored by Bharath Kumar Kuruba, Nusrathulla Shariff, Samuel Vasanthkumar, Lourdusamy Emmanuvel

For the first time, we have observed a combined effect of two bases NaOH/Et₃N to promote the diazo transfer reaction of β-oximino esters. This unusual synergistic effect has been employed to obtain α-diazo oxime ethers directly from β-keto esters by one-pot process. This method is simple and cost-effective and the reagents are readily available.