Neolignan and phenylpropanoid compounds from the fruits of <i>Illicium simonsii</i> Maxim

<p>One new sesqui-neolignan compound, namely, sesqui-illisimonan A (<b>1</b>), one new neolignan, illisimonan A (<b>2</b>), and one new phenylpropanoid compound, illisimoid A (<b>3</b>) were isolated from the fruits of <i>Illicium simonsii</i> Maxim. The structures and absolute configurations of these compounds were determined by extensive spectroscopic, including NMR, circular dichroism and calculated electronic circular dichroism methods. The antioxidant activities of compounds <b>1</b>–<b>3</b> were also evaluated. Vitamin E was selected as the positive control (IC<sub>50</sub> = 49.73 ± 0.88 μM). Compounds <b>1</b> and <b>2</b> exhibited <i>in vitro</i> antioxidant activity with an IC<sub>50</sub> value of 55.76 ± 1.30 and 59.36 ± 0.50 μM, respectively. However, the compound <b>3</b> didn’t show obvious antioxidant activity.</p>