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New butenolides with anti-inflammatory activity from Balanophora fungosa

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journal contribution
posted on 30.07.2019 by Jie Zhou, Si-Yu Du, Zhong-Ying Fang, Zhi Zeng

Two new butenolides, balanolides A (1) and B (1), were isolated from the aerial parts of the parasitic plant Balanophora fungosa. Their structures were established by comprehensive spectroscopic analysis and quantum chemical ECD calculation. The new butenolides were evaluated for their inhibitory effects against nitric oxide (NO) production in LPS-induced RAW 264.7 macrophage cells. Compounds 1 and 2 displayed moderate anti-inflammatory activity with IC50values of 11.8 and 12.9 μM, respectively.

Funding

This work was supported by Natural Science Foundation of China (81673527), the National Key Research and Development Project (2017YFC1702702, 2017YFC1700705), and the Construction Project for Sustainable Utilization of Valuable Traditional Chinese Medicine Resources (2060302).

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