New conjugates of mycophenolic acid and their antiproliferative activity

<p>The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of <i>N</i><sup>6</sup>-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds <b>4a–h</b> were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound <b>4b</b> possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.</p>