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New dammarane-type triterpenoid glycosides from Gynostemma burmanicum

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Version 2 2020-01-07, 13:00
Version 1 2018-12-22, 13:14
journal contribution
posted on 2020-01-07, 13:00 authored by Thi Kieu My Than, Thanh Ky Pham, Thanh Binh Pham, Thao Nguyen Phuong, Dat Nguyen Tien

The chemical composition of Gynostemma burmanicum King ex Chakrav. was investigated for the first time in this study. Nine dammarane glycosides (19) were isolated from the EtOH extract of the aerial parts of G. burmanicum. Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The new compounds were 3β,20S-dihydroxydammar-24-ene-3-O-β-D-glucopyranosyl-20-O-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside] (1), 3β,12β,20S-trihydroxydammar-24-ene-3-O-β-D-xylopyranosyl-20-O-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside] (2), and 12-oxo-3β,20S-dihydroxydammar-24-ene-3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside] (3).

Funding

This work is supported by the Department of Botany, Hanoi University of Pharmacy. We thank the Institute of Chemistry (VAST) for the NMR experiments.

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