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New phenyl derivatives from endophytic fungus Botryosphaeria sp. SCSIO KcF6 derived of mangrove plant Kandelia candel

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posted on 2015-06-29, 00:00 authored by Zhi-ran Ju, Xiaochu Qin, Xiu-Ping Lin, Jun-Feng Wang, Kumaravel Kaliyaperumal, Yong-qi Tian, Juan Liu, Fen Liu, Zhengchao Tu, Shi-Hai Xu, Yonghong Liu

Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 17 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12 μM.

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