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Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial activities

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Version 2 2016-12-05, 15:48
Version 1 2016-10-07, 17:25
journal contribution
posted on 2016-12-05, 15:48 authored by Garbapu Suresh, Ratnakaram Venkata Nadh, Navuluri Srinivasu, Kishore Kaushal

A highly efficient and mild protocol for the syntheses of ethyl-3-[7-benzyloxy-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates and ethyl-3-[7-benzyloxy-3-chloro-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates in good yields via [3 + 2] cycloaddition of in situ–generated nitrile oxides from 7-benzyloxy-4-methyl-coumarin hydroxymoylchlorides and 7-benzyloxy-3-chloro-4-methyl-coumarin hydroxymoylchlorides respectively with ethyl-3-aryl prop-2-enoate has been developed. The new compounds are screened for antibacterial activity.

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