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Novel thiazolinyl-picolinamide based palladium(II) complex-impregnated urinary catheters quench the virulence and disintegrate the biofilms of uropathogens

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posted on 2020-05-13, 16:15 authored by Deeksha Rajkumar, Durairajan Rubini, M. Sudharsan, D. Suresh, Paramasivam Nithyanand

Pseudomonas aeruginosa and Serratia marcescens are prominent members belonging to the group of ESKAPE pathogens responsible for Urinary Tract Infections (UTI) and nosocomial infections. Both the pathogens regulate several virulence factors, including biofilm formation through quorum sensing (QS), an intercellular communication mechanism. The present study describes the anti-biofilm and QS quenching effect of thiazolinyl-picolinamide based palladium(II) complexes against P. aeruginosa and S. marcescens. Palladium(II) complexes showed quorum sensing inhibitory potential in inhibiting swarming motility behaviour, pyocyanin production and other QS mediated virulence factors in both P. aeruginosa and S. marcescens. In addition, the establishment of biofilms was prevented on palladium (II) coated catheters. Overall, the present study demonstrates that thiazolinyl-picolinamide based palladium (II) complexes will be a promising strategy to combat device-mediated UTI infections.

Funding

Financial support from Department of Biotechnology (DBT), Ministry of Science and Technology, New Delhi (BT/PR/23592/MED/29/1203/2017) awarded to PN is gratefully acknowledged. Financial support from Department of Science and Technology (DST), India (YSS-2014-000217) awarded to DS is also acknowledged. The Fellowship to DR in the form of JRF by DBT is thankfully acknowledged, as is the Fellowship to MS in the form TA by SASTRA.

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