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One-pot three-component reaction of arylglyoxals with acetylthiourea and Meldrum’s acid or barbituric acid for synthesis of new 2-acetamido-4-arylthiazol-5-yl derivatives

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journal contribution
posted on 2019-04-05, 15:01 authored by Farzaneh Alizadeh-Bami, Hossein Mehrabi, Reza Ranjbar-Karimi

An efficient method for the synthesis of 2-acetamido-4-arylthiazol-5-yl derivatives via a novel one-pot three-component reaction of arylglyoxals, 1,3-dicarbonyl compounds such as Meldrum’s acid or barbituric acid, and acetylthiourea in ethanol is reported.

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