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Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

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posted on 2019-09-18, 07:03 authored by Luděk Záveský, Eva Jandáková, Vít Weinberger, Luboš Minář, Veronika Hanzíková, Daniela Dušková, Lenka Záveská Drábková, Aleš Hořínek

Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.

Funding

LZ received institutional funding from Charles University, Prague (Progres Q28/LF1) and research support from the Avast Foundation (0F2016\2016020048, SSD2018\100022), CEZ Foundation (STE EPP 126_16) and ČEPS a.s. (1410001544, 1410002088). AH received institutional funding from Charles University, Prague (Progres Q25/LF1) and research support from the Ministry of Health of the Czech Republic (grant project RVO-VFN 64165). VW and LM received research support from the Ministry of Health of the Czech Republic (CZ-DRO FNBr 65269705).

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