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Performance of Topological Perception in the Myopic Population

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journal contribution
posted on 2020-04-27, 06:04 authored by Yi Sun, Fei Li, Hao Li, Yunhe Song, Wenbo Wang, Rouxi Zhou, Jian Xiong, Wanbing He, Yuying Peng, Yuhong Liu, Liping Wang, Yan Huang, Xiulan Zhang

Purpose: Discriminating objects’ topological property (TP) is a primitive function of visual representation, which is reported to be associated with magnocellular (M) visual pathway, temporal lobe (TL), and superior colliculus (SC)-pulvinar subcortical pathway. Previous studies have shown that M pathway and TL were affected in high myopia (HM) subjects. The study was accordingly designed to explore whether topological perception performance was abnormal in HM subjects.

Methods: 30 mildly myopic, 25 moderately myopic, 35 highly myopic, and 20 emmetropic subjects were enrolled. All participants underwent a comprehensive ophthalmological assessment including automated refraction, intraocular pressure, Humphrey 10–2 standard automated perimetry, ocular fundus photography and swept-source optical coherence tomography. Defined by differences in hole, TP and non-TP discrimination with letters “E”, “S”, “P”, “d” as stimuli in the central and peripheral regions was performed using the MATLAB 2017 software. d-primes extracted from the software were analyzed within each group. The correlation of peripheral TP/non-TP deficit with spherical equivalent (SE), axial length (AL) and average peripapillary retinal nerve fiber layer (RNFL) thickness was performed.

Results: The patterns of topological perception performance were similar among the groups. TP discrimination peripherally was significantly better than that centrally in the mild myopia (P < .001), moderate myopia (P < .001), high myopia (P < .001) and emmetropia groups (P = .001). In the peripheral region, TP d-prime scores were significantly better than non-TP d-prime scores (all P < .001). The main and interaction effects of eccentricity and stimulus type were statistically significant(P < .05). There was no statistically significant correlation between peripheral TP/non-TP deficit and SE, AL or average RNFL thickness (P > .05).

Conclusions: The current study first showed that patterns of topological perception among the myopic population were similar and not affected by the severity of myopia.

Funding

This study was supported by the Science and Technology Planning Projects of Guangdong Province [2017B030314025]; the Science and Technology Program of Guangzhou [201803010066]; the Guangdong Key Lab of Brain Connectome.

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