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Polycyclic polyprenylated acylphloroglucinols from Hypericum choisianum

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journal contribution
posted on 2019-05-31, 12:02 authored by Hai-Bo Zhang, Xu Zhang, Kun Jiang, Shi-Jin Qu, Ling-Hua Meng, Qun Lu, Chang-Heng Tan

Twenty-one polycyclic polyprenylated acylphloroglucinols, including three new compounds named as hyperichoisins A (3), B (14) and C (21), were isolated from the aerial parts of Hypericum choisianum. The structures of those new compounds were elucidated by analysis of mass, NMR data, and chiroptical properties. A bioassay showed that otogirinin B had significant inhibitory effect on cell proliferation of A549.

Funding

This study was financially supported by grants from the National Science & Technology Major Project Key New Drug Creation and Manufacturing Program (Nos. 2018ZX09201001-001-005, 2018ZX09201001-001-007 and 2018ZX09735001-002-005) of the Ministry of Science and Technology, China.

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    Natural Product Research

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    Hypericum choisianumPPAPsHyperichoisins A – CNMR analysis

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