gpss_a_1673749_sm0469.doc (1.17 MB)
Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol
journal contribution
posted on 2019-10-07, 11:57 authored by Ilyas S. Nizamov, Ramazan Z. Salikhov, Ildus D. Timushev, Yevgeniy N. Nikitin, Ilnar D. Nizamov, Vladimir Yu. Yakimov, Marina P. Shulaeva, Oscar K. Pozdeev, Elvira S. Batyeva, Rafael A. Cherkasov, Anna S. PonomarevaA new series of chiral carboxypyridinium dithiophosphates were synthesized by the reactions of nicotinic, isonicotinic, and picolinic acids with dithiophosphoric acid on the basis (1S)-endo-(–)-borneol in benzene or ethanol. 5,5-Dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane reacted with 3-hydroxypyridine or 3-pyridinemethanol in EtOH to afford the 3-hydroxypyridinium and 3-hydroxymethylpyridinium 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinanes which possessed antifungal activity against Candida albicans.