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Real-world treatment patterns and associated progression-free survival in relapsed/refractory multiple myeloma among US community oncology practices

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posted on 2016-06-16, 23:09 authored by Sundar Jagannath, Anuja Roy, Jonathan Kish, Orsolya Lunacsek, Denise Globe, Michael Eaddy, Emil T. Kuriakose, Joanne Willey, Stephanie Butler-Bird, David Siegel

Background: Evidence supporting optimal treatment sequencing in relapsed/refractory multiple myeloma (RRMM) patients requiring multiple therapy lines is lacking.

Methods: Using retrospective chart data, this study describes real-world RRMM treatment patterns and related progression-free survival (PFS) in US community oncology clinics.

Results: Bortezomib ± a non-immunomodulatory drug (IMiD), lenalidomide ± a non-proteasome inhibitor (PI), bortezomib + an IMiD were the most commonly used regimens in early lines of therapy. Median PFS was similar in 1st (11.1 months) and 2nd line (10.5) and decreased in lines 3 through 5 (3rd: 7.9; 4th: 7.2, 5th: 5.4). Longest PFS (12.5 months) in first line was with bortezomib + ImiD; longest PFS in second line was with lenalidomide ± a non-PI was (13.2 months).

Conclusions: Re-treatment with bortezomib was common; novel agents were reserved for later therapy lines. Overall, the observed PFS associated with real-world treatment sequences were shorter than those reported in clinical trials.

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