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RhIII-catalyzed annulation of N-methoxyindozamides with heterobicyclic alkenes towards indolo[3,2-c]heteroarenes

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posted on 2018-07-11, 16:11 authored by Ping Li, Jiancheng Wang, Han Li, Wanrong Dong, Zhihong Peng, Delie An

A rhodium-catalyzed annulation protocol towards indolo[3,2-c]-1-azaanthraenes and successive treatment with different acids, which offered diverse indolo[3,2-c]-heteroarenes, were herein demonstrated. The transition metal-mediated system offered a direct and facile approach towards the heterocyclic compounds of great significance, enjoying high efficiency and good functional groups compatibility.

An annulation reaction between N-methoxyindozamides and heterobicyclic alkenes was herein disclosed. The Rh-Ag-cocatalyzed system offered a direct approach towards various indolo[3,2-c]-1-azaanthraenes in high efficiency and good functional group tolerance. Successive treatment of acids gave different products of great importance.

Funding

The authors are grateful for the financial support from the Natural Science Foundation of Hunan Province (grant No. 2017JJ3027), the Fundamental Research Funds for Hunan University (grant No. 531107040840).

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