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Simvastatin delivery on PEEK for bioactivity and osteogenesis enhancements

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journal contribution
posted on 2018-12-07, 12:58 authored by Li-Jun Deng, Yan-Lin Wu, Xian-Hua He, Ke-Nan Xie, Lu Xie, Yi Deng

A strategy developed for obtaining positive cellular responses remains to be focused in the filed of functional biomimetics. In this study, a hydrogel covered simvastatin-loaded polyetheretherketone (PEEK) bio-composites was constructed with the purpose of bone tissue regeneration therapy. Briefly, a three-dimensional (3D) porous structure was fabricated on PEEK surface; then the substrate was functionalized with the poly(L-lactic acid)/simvastatin porous film and hyaluronic acid hydrogel subsequently. In vitro cell attachment, proliferation, and cytoskeletal observation experiments reveal that our scaffolds show better bio-affinity due to the layer of hyaluronic acid hydrogel compared with control. Furthermore, the alkaline phosphatase activity, calcium mineral deposition evaluation, and gene expression for osteogenic potential all exhibit that the superior osteogenic differentiation of MC3T3-E1 pre-osteoblasts on our scaffolds. Therefore, our PEEK samples loaded with simvastatin and covered with hyaluronic acid hydrogel hold great potential in clinical applications for bone repair.

Funding

This work was jointly supported by the Fundamental Research Funds for the Central Universities (2012017yjsy176, and Full-time Postdoctoral Research Funding of SCU [2017SCU12016, 2017SCU12057]), the National Natural Science Foundation of China (No. 81801848), Sichuan Science and Technology Program (2017FZ0046, 2018JZ0026), China Postdoctoral Science Foundation (2017M610600), the International Science and Technology Cooperation Funding of Chengdu (2017-GH02-00025-HZ), as well as Hong Kong Scholars Program.

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