Structural diversity and similar bioactivity in synthetic bicyclononanes

<p>Simple syntheses of diverse bicyclo[3.3.1]nonanes and related compounds as the minimal substructure of bioactive natural products via Michael, aldol, and alkylation reactions from diketones are described herein. The structures of the synthesized compounds were determined by infrared spectroscopy, NMR (<sup>1</sup>H and <sup>13</sup>C), and electrospray ionization–high-resolution mass spectrometry. We also show the in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria. The qualitative analysis has revealed that the new synthesized compounds <b>5, 6, 9,</b> and <b>11</b> present antibacterial properties.</p>