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Synthesis and investigation of antimicrobial activity of compounds derived from benzo[C][1,2,5]oxadiazole-1-oxides and phenolates

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posted on 09.09.2016 by Elena A. Chugunova, Nurgali I. Akylbekov, Alexandra D. Voloshina, Natalia V. Kulik, Vladimir V. Zobov, Vasily M. Babaev, Nikolai V. Gavrilov, Alexander R. Burilov

(Di)chloro(di)nitrobenzofuroxans form substitution products involving carbon atoms with phenolates in isopropyl alcohol medium. In the case of 4,6-dinitro-5,7-dichlorobenzofuroxan, besides replacement of one chlorine atom and the formation of C-bonded product, we observed the hydrolysis of the second chlorine and replacement of it by hydroxyl group. Products of reaction of 4,6-dichloro-5-nitrobenzofuroxan with phenolates display excellent antimicrobial activity and have dual action, both against bacteria and fungi.

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