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Synthesis and antitubercular activity evaluation of 4-furano-coumarins and 3-furano-chromones

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posted on 08.10.2018 by Ankita Singh, Devla Bimal, Rajesh Kumar, Vipin K. Maikhuri, M. Thirumal, Nihar Nalini Senapati, Ashok K. Prasad

The synthesis of novel 4-furano-coumarins and 3-furano-chromones has been achieved using silver-mediated oxidative C–H/C–H functionalization of 4-ethynylcoumarin/3-ethynylchromone with ethyl acetoacetate in 80%–90% and 82%–90% yields, respectively. The structure of the synthesized compounds was established on the basis of their spectral data analysis and the structure of one of the 4-furano-coumarins has been further confirmed on the basis of its X-ray crystallographic study. All eight synthesized 4-furano-coumarins and 3-furano-chromones exhibited moderate antitubercular activity against sensitive reference strain H37Rv of Mycobacterium tuberculosis.

Funding

We are grateful to the University of Delhi for providing financial support under DU-DST Purse Grant and under scheme to strengthen research and development. A.S. thanks DRDO for the Junior Research Fellowship. D.B. and R.K. thank CSIR for Senior Research Fellowship.

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