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Synthesis and biophysical analysis of Naringin-Chitooligosaccharide complex

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journal contribution
posted on 13.06.2019 by Ruge Cao, Xueyang Li, Zhongkai Zhou, Zhenyu Zhao

In this study, new complexes of Naringin and Chitooligosaccharide (Nari-COS) at different mole ratios (1:1, 1:5, 1:10) were prepared by spray-drying method so as to enhance the water solubility and weaken the bitterness of naringin. At the same time, the antioxidant and the antibacterial properties of this complex were evaluated. SEM, FTIR, 1H NMR analysis confirmed the successful synthesis of Nari-COS formed through hydrogen bonds between the A, B rings of naringin and COS. Nari-COS exhibited significantly better water solubility, reduced bitterness, stronger antioxidant capacity, and enhanced antibacterial property in comparison to pure naringin, benefitting the extensive application of natural products in foods.


This study was financially supported by the National Natural Science Foundation of China (U1501214 and 31601477), the Scientific Research Project of Tianjin Municipal Education Commission (2018KJ091) and Program of Beijing Advanced Innovation Center for Food Nutrition and Human Health (20181037).