Taylor & Francis Group
Browse
gcoo_a_1693041_sm0031.docx (8.14 MB)

Synthesis and evaluation of Zn(II) dithiocarbamate complexes as potential antibacterial, antibiofilm, and antitumor agents

Download (8.14 MB)
journal contribution
posted on 2019-11-22, 13:19 authored by Vinay Kumar Maurya, Ashish Kumar Singh, Ravi Pratap Singh, Shivangi Yadav, Krishna Kumar, Pradyot Prakash, Lal Bahadur Prasad

Four complexes having the formula [Zn(L)2] [L1 = (C18H20NS2), N-(4-isopropyl-benzyl)-(benzyl)-dithiocarbamate], [L2 = (C10H12NS2), N-(benzyl)-(ethyl)-dithiocarbamate], [L3 = (C19H22ONS2), N-(4-isopropyl-benzyl)-(4-methoxy-benzyl)-dithiocarbamate], and [L4 = (C16H16NS2), N-(benzyl)-(4-methyl-benzyl)-dithiocarbamate] have been contemplated, synthesized, and characterized by elemental analysis and IR, 1H, 13C NMR and UV–visible absorption spectra. All Zn(II) complexes have similar geometry and coordination number. Complex A2 (with ligand L2) crystallizes in triclinic system with space group P-1 having distorted square pyramidal geometry which was stabilized by weak C–H···π and C–H···S intramolecular interactions. The antibacterial, antibiofilm, and antitumor activities of the complexes have been screened and A2 and A3 showed their prominence. Interestingly, both A2 and A3 showed more killing potential against multi-drug resistant gram-positive isolates with MIC indices of 16 μg mL−1 and 16 μg mL−1, respectively, against both MRSA and MSSA, while the antitumor agent A3 showed its prominence with GI50 and LC50 41.15 and 133.73 µg mL−1, respectively.

Funding

We sincerely acknowledge the DST-PURSE grant sanctioned to Department of Microbiology, IMS, BHU. VKM, AKS are also acknowledging University Grant Commission (UGC), New Delhi for Senior Research Fellow Ref. No: 22/12/2013 (II) EU-V and 22/06/2014 (i) EU-V, respectively, and SY acknowledges Council of Scientific and Industrial Research, New Delhi for financial assistance in the form of Junior research fellow ref. no. [1121630870 vide 18/12/2016 (ii) EU-V].

History