ganp_a_1760851_sm9019.doc (2 MB)
Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin
journal contribution
posted on 2020-05-22, 12:20 authored by Xiao-Lei Huang, Jing-Lei Chen, Xian-Lun Li, Lei Zhao, Ya-Dong Cui, Jiang-Yun Liu, Susan L. Morris-Natschke, Goto Masuo, Yung-Yi Cheng, Kuo-Hsiung Lee, Dao-Feng Chen, Jian ZhangFourteen glaucocalyxin A biotinylated derivatives, one glaucocalyxin C biotinylated derivative, and two oridonin biotinylated derivatives were designed and synthesized. Their structures were confirmed from 1H NMR, 13C NMR and HRMS data. The derivatives were evaluated for cytotoxic activities against lung (A549), cervical cancer cell line HeLa derivative (KB), multidrug-resistant KB subline (KB-VIN), triple-negative breast (MDA-MB-231), and estrogen receptor-positive breast (MCF-7) cancer cell lines.