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Synthesis of 3-acylated indoles through iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds

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Version 2 2017-10-05, 14:36
Version 1 2017-08-11, 13:54
journal contribution
posted on 2017-10-05, 14:36 authored by Niannian Yi, Jinxia Li, Hao Zhang, Ruijia Wang, Jun Jiang, Wei Deng, Zebing Zeng, Jiannan Xiang

A novel iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds has been developed. The transformation provides an attractive approach to the synthesis of 3-acylindoles, with the advantages of easily available starting materials and high functional group tolerance. Furthermore, control experiments imply that a radical process maybe involved in this reaction.

Funding

This work was supported by the National Natural Science Foundation of China [Grant Number 21502049,51573040], Planned Science and Technology Project of Hunan Province, China [Grant Number 2015WK3003], and Hunan Provincial Innovation Foundation for Postgraduate [Grant Number CX2015B076]

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