lsyc_a_1364767_sm4082.pdf (2.36 MB)
Synthesis of 3-acylated indoles through iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds
Version 2 2017-10-05, 14:36
Version 1 2017-08-11, 13:54
journal contribution
posted on 2017-10-05, 14:36 authored by Niannian Yi, Jinxia Li, Hao Zhang, Ruijia Wang, Jun Jiang, Wei Deng, Zebing Zeng, Jiannan XiangA novel iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds has been developed. The transformation provides an attractive approach to the synthesis of 3-acylindoles, with the advantages of easily available starting materials and high functional group tolerance. Furthermore, control experiments imply that a radical process maybe involved in this reaction.