Synthesis of 3-(3-Methyl-1-aryl-1<i>H</i>-pyrazol-5-yl)-2<i>H</i>-2-chromen-2-one Derivatives via a One-Pot, Three-Component Reaction

2014-05-14T15:49:37Z (GMT) by Abdolali Alizadeh Rashid Ghanbaripour
<div><p></p><p>An efficient synthesis of 3-(3-methyl-1-aryl-1<i>H</i>-pyrazol-5-yl)-2<i>H</i>-2-chromen-2-one derivatives by the reaction of salicylaldehydes, 4-hydroxy-6-methyl-2<i>H</i>-pyran-2-one, and arylhydrazine in acetonitrile under reflux condition and in the presence of piperidine is reported. This three-component reaction has some advantages such as ease of handling, good yields, and easy purification. All structures were confirmed by infrared, mass, <sup>1</sup>H NMR, and <sup>13</sup>C NMR spectroscopy.</p> </div>