lsyc_a_1027405_sm1186.pdf (429.88 kB)
Synthesis of Functionalized Dihydrofurocoumarin Derivatives from 3-Aminoalkyl-4-hydroxycoumarin
Version 3 2015-05-21, 14:13
Version 2 2015-05-21, 14:13
Version 1 2015-05-21, 14:13
journal contribution
posted on 2015-05-21, 14:13 authored by Pallabi Borah, P. Seetham Naidu, Pulak J. BhuyanSome dihydrofuro-fused coumarin derivatives were synthesized from 3-aminoalkyl-4-hydroxycoumarin via in situ generation of N-ylide. The 3-aminoalkylated 4-hydroxycoumarin derivatives were synthesized from one-pot, three-component reaction of 4-hydroxycoumarin, aryl aldehydes, and secondary amines in ethanol at room temperature. Again, when salicylaldehyde was employed instead of benzaldehyde, interestingly pyranocoumarins were obtained. The reaction protocol can be further explored toward the synthesis of many other heterocyclic fused dihydrofurans.