lsyc_a_1021425_sm0128.pdf (1.91 MB)
Synthesis of Novel Saccharide Hydrazones
Version 2 2015-04-16, 21:16
Version 1 2015-04-16, 21:16
journal contribution
posted on 2015-04-16, 21:16 authored by Mihkel Ilisson, Kristjan Tomson, Anastasia Selyutina, Silver Türk, Uno MäeorgSynthesis of important heterocyclic hydrazine derivatives N-aminopyrrolidine, N-aminopiperidine, and N-aminoazepane from hydrazine hydrate and dihalogenides were examined and optimized. These heterocyclic hydrazine derivatives were used in condensation reactions with six different monosaccharides to form corresponding hydrazones. Biological evaluations of these novel compounds, which are simple acyclic nucleoside analogs, were done. L-Arabinose N-aminoazepane hydrazone showed minor anti-HIV activity, giving a starting point for further structural modifications.