Synthesis of Pyrano[2, 3-d]Pyrimidine-2,4(3H)-Dione Derivatives Based-on Curcumin Using NiCo₂O₄@OCMC@Zn(BDC) Nanocomposite as a Novel and Efficient Catalyst

Curcumin, a category of phenolic compound derivatives from the base of Curcuma longa (Zingiberaceae), represent a variety of beneficial effects on health and on events that succor in hampering certain diseases. The present research explains an efficient procedure for the synthesis of pyrano[2,3-d] pyrimidine-2,4(3H)-diones in high yields and short response times via a three-ingredient reaction of curcumin, aromatic aldehydes and 1,3-dimethylbarbituric acid in the presence of NiCo₂O₄@OCMC@Zn(BDC) nanocomposite. The catalyst was determined by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared, (FT-IR) X-ray powder diffraction (XRD) and Brunauer–Emmett–Teller (BET). Moreover, the NiCo₂O₄@OCMC@Zn(BDC) catalyst can be recovered and reused several times without significant loss of its activity.