Synthesis of N-(2-(Methylamino)ethyl) Derivatives of 2H-Phthalazin-1-ones

Malinowski, Zbigniew; K. Szcześniak, Aleksandra; Pakulska, Wanda; Sroczyński, Dariusz; Czarnecka, Elżbieta; Epsztajn, Jan

doi:10.6084/m9.figshare.1132638.v4

lsyc_a_944269_sm3631.pdf (1.06 MB)

Synthesis of N-(2-(Methylamino)ethyl) Derivatives of 2H-Phthalazin-1-ones

Version 4 2014-10-21, 00:39

Version 3 2014-10-21, 00:39

Version 2 2014-10-17, 21:59

Version 1 2014-10-21, 00:39

journal contribution

posted on 2014-10-21, 00:39 authored by Zbigniew Malinowski, Aleksandra K. Szcześniak, Wanda Pakulska, Dariusz Sroczyński, Elżbieta Czarnecka, Jan Epsztajn

A series of new alkyl, tosyl, acetyl, and tert-butoxycarbonyl derivatives of 2-(2-aminoethyl)-phthalazinones were efficiently synthesized by reaction of lactams with N-Boc-, N-acetyl-, or N,O-ditosyl derivatives of N-methylethanolamine in the presence of MeONa or under Mitsunobu reaction conditions. Selected compounds were converted into corresponding 2-[2-(methylamino)ethyl]phthalazinones in good yields.