Taylor & Francis Group
Browse
lsyc_a_1551548_sm5150.doc (2.64 MB)

Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction

Download (2.64 MB)
journal contribution
posted on 2019-02-20, 07:35 authored by Waléria F. Rabêlo, Radell Echemendía

In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.

Funding

This work was supported by the CNPq under [Grant 141770/2015-5].

History