lsyc_a_1551548_sm5150.doc (2.64 MB)
Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction
journal contribution
posted on 2019-02-20, 07:35 authored by Waléria F. Rabêlo, Radell EchemendíaIn an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.