TBHP-Mediated Oxidative Cross-Coupling of Disulfides with Ethers through a C(sp3)-H Thiolation Process

2014-06-09T18:53:23Z (GMT) by Ya-Ping Hu Ri-Yuan Tang

A new tert-butyl hydroperoxide (TBHP)–mediated oxidative cross-coupling of disulfides with ethers is presented for the synthesis of etherified sulfides. This method is achieved by a C(sp3)-H thiolation strategy under metal-free conditions and provides a simple route to constructing the C-S bonds.