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Three new resin glycosides compounds from Argyreia acuta and their α-glucosidase inhibitory activity

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journal contribution
posted on 2016-07-11, 18:30 authored by Li Wang, You-Shao Yan, Hong-Hua Cui, Yong-Qin Yin, Jie-Tao Pan, Bang-Wei Yu

Three new phenolic compounds, acutacoside C (1), acutacoside D (2) and acutacoside E (3) were isolated from the aerial part of Argyreia acuta. The oligosaccharide chain was composed of two glucoses and three rhamnoses, and the aglycone was (11S)-hydroxyhexadecanoic acid (jalapinolic acid). The core of the three compounds was operculinic acid B, which was rare in resin glycosides. Their structures were established by a combination of spectroscopic and chemical methods. Compounds 1-3 have been evaluated for inhibitory activity against α-glucosidase, which all showed weak inhibitory activities.

From the aerial parts of Argyreia acuta, three new pentasaccharide compounds were isolated, identified and evaluated for their a-glucosidase inhibition activity.

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