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Triglyceride accumulation inhibitory effects of new chromone glycosides from Drynaria fortunei

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journal contribution
posted on 04.08.2015 by Lifeng Han, Fang Zheng, Yi Zhang, Erwei Liu, Wei Li, Minghui Xia, Tao Wang, Xiumei Gao

Two new chromone glycosides, drynachromosides C (1) and D (2), along with five known chromones (37), were isolated from the rhizomes of Drynaria fortunei. The structures of the two new compounds were elucidated on the basis of physico-chemical property and spectroscopic data. Triglyceride (TG) accumulation inhibitory effects of the obtained chromones on 3T3-L1 cells were investigated. The results showed that 1, 2 and 5 exhibited inhibitory activity on TG accumulation. Effects of compounds 1 and 2 on mRNA expression of PPARγ, C/EBPα and aP2 in 3T3-L1 cells were also investigated.