Two new flavones glycosides with antimicrobial activities from <i>Clerodendrum formicarum</i> Gürke (Lamiaceae)

<p><i>Clerodendrum formicarum</i> Gürke from the Lamiaceae family is a Cameroonian medicinal plant. The crude methanol, methanol residual and ethyl acetate extracts of leaves have been phytochemically studied using chromatography column to afford four compounds; two new flavones glycoside: clerodendronone 1a (<b>3</b>) and clerodendronone 1b (<b>4</b>) along with two known compounds: 5,7-dihydroxy-4′-methoxyflavone (<b>1</b>) and 5-hydroxy-7,4′-dimethoxyflavone (<b>2</b>). Compound structures have been elucidated on the basis of their spectroscopy data and with literature information. The anti-microbial activities of extracts and three isolated compounds were performed. The antibacterial activity was evaluated against four gram positive, five gram negative and three fungus. Clerodendronone 1b (<b>4</b>) showed good antibacterial activity against bacterial gram negative <i>Shigella flexineri</i> NR518 (MIC = 62.5 μg/ml) and moderate activity against <i>Staphylococcus aureus</i> NR46374 (MIC = 250 μ/ml). The ethyl acetate extract recorded good antibacterial activity against <i>Staphylococcus aureus</i> NR46003 (MIC = 125 µg/ml) and <i>Staphylococcus aureus</i> NR46374 (MIC = 125 μg/ml).</p>