Two new <i>ent</i>-kaurane diterpenes from the stems of <i>Eurya chinensis</i>

<p>Two new <i>ent</i>-kaurane diterpenes (<b>1</b>–<b>2</b>), together with five known analogs, were isolated from the stems of <i>Eurya chinensis</i>. The structures of new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound <b>3</b> exhibited noticeable anti-inflammatory activity as denoted by inhibiting LPS-induced nitric oxide (NO) production in RAW264.7 cells with an IC<sub>50</sub> value of 7.82 μM. Compound <b>4</b> showed potent cytotoxic activity against human cancer cell lines NCI-H46, HepG2 and SW480 with IC<sub>50</sub> values ranging from 7.45 to 8.54 μM.</p>