gnpl_a_1354189_sm8346.pdf (1.08 MB)
Two new linear acetogenins from the fruits of Goniothalamus gracilipes
journal contribution
posted on 2017-07-17, 06:21 authored by Quy Hung Trieu, Huong Doan Thi Mai, Marc Litaudon, Dao Phi Thi, Tuan Anh Tran, Van Hung Nguyen, Van Minh Chau, Van Cuong PhamTwo new linear acetogenins, gracilipin A (1) and methylsaccopetrin A (2) along with seven known compounds, saccopetrin A (3), 7,3′,4′-trimethylquercetin (4), rhamnazin (5), casticin (6), isokanugin (7), melisimplexin (8) and 5-hydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (9) were isolated from the fruits of Goniothalamus gracilipes Bân. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR, 2D-NMR and circular dichroism (CD). Compounds 1 and 3 showed cytotoxic activity against KB cell line with IC50 values of 14.6 and 15.3 μM, respectively.