Two new macrosporin dimers from the fungus Alternaria sp. XZSBG-1

Chen, Bin; Liu, Lan; Zhu, Xun; Wang, Jun; Long, Yi; Jiang, Si-Ping; Xu, Ai-Guo; Lin, Yong-Cheng

doi:10.6084/m9.figshare.1286779.v3

gnpl_a_997232_sm8851.doc (875 kB)

Two new macrosporin dimers from the fungus Alternaria sp. XZSBG-1

Version 3 2015-07-22, 08:28

Version 2 2015-07-22, 08:28

Version 1 2015-07-03, 00:00

journal contribution

posted on 2015-07-22, 08:28 authored by Bin Chen, Lan Liu, Xun Zhu, Jun Wang, Yi Long, Si-Ping Jiang, Ai-Guo Xu, Yong-Cheng Lin

Two new macrosporin dimers (1–2) along with four known compounds (3–6) were isolated from the extracts of the fungal strain Alternaria sp. XZSBG-1 from the sediment of the salt lake in the Bange, Tibetan, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compounds 1 and 2 are new macrosporin dimers with symmetric chemical structures. In the cytotoxicity assay and inhibited alpha-glucosidase activity assay, all these compounds showed no notable inhibitory activity.