Taylor & Francis Group
Browse
ganp_a_1576643_sm0361.doc (21.92 MB)

Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopus japonicus

Download (21.92 MB)
journal contribution
posted on 2019-06-13, 11:41 authored by Xuan-Ming Zhang, Li-Wen Han, Wen-Long Sheng, Xiao-Bin Li, Shan-Shan Zhang, Jing-Lan Guo, Hou-Wen Lin, Ke-Chun Liu

Two novel glycosides, apostichoposide A1 (1) and B1 (2), were isolated from the viscera of Chinese sea cucumbers (Apostichopus japonicus, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound 1 had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in A. japonicus viscera are an important high value resource for biotechnological applications.

History