letter_FuPaper_SBR_supplRcode.R (3.22 kB)
“Step-Down Parametric Procedures for Testing Correlated Endpoints in a Group-Sequential Trial” by Yiyong Fu
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posted on 2019-04-22, 15:11 authored by Marcel Wolbers, Ekkehard Glimm, Dong XiFu (2018) developed a parametric consonant closed testing procedure for correlated endpoints in a group-sequential design. In their approach, correlations between endpoints are exploited leading to a proportional up-scaling of local significance levels from Holm’s weighting scheme. We challenge the claim that the proposed calculation of the up-scaling factor leads to a test that protects the type I error in the group-sequential setting and outline two alternative approaches which do lead to exact error control.