“Step-Down Parametric Procedures for Testing Correlated Endpoints in a Group-Sequential Trial” by Yiyong Fu

2019-04-22T15:11:01Z (GMT) by Marcel Wolbers Ekkehard Glimm Dong Xi

Fu (2018) developed a parametric consonant closed testing procedure for correlated endpoints in a group-sequential design. In their approach, correlations between endpoints are exploited leading to a proportional up-scaling of local significance levels from Holm’s weighting scheme. We challenge the claim that the proposed calculation of the up-scaling factor leads to a test that protects the type I error in the group-sequential setting and outline two alternative approaches which do lead to exact error control.