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Cecropia hololeuca: A new source of compounds with potential anti-inflammatory action

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posted on 11.09.2019 by Emanuelle G. Machado, Oswaldo Cardoso Jr, Nerilson M. Lima, Paloma E. Carvalho, Alice D. Barbosa, Guilherme F. S. Sobrinho, Jennifer F. Duarte, Laryssa R. Coelho, Pietra P. C. Soares, Ayane G. Orneles, Ana Carolina B. Santos, Kamila B. Santos, Sandra B. R. Castro, Marcone A. L. de Oliveira, Alessandra P. Carli, Caio Cesar Souza Alves

Our objective is to investigate the phytochemical components, antioxidant capacity and in vitro and in vivo anti-inflammatory action from Cecropia hololeuca bark aqueous extract (AECh). The chemical characterization of AECh was performed through CE-UV, FTIR and NMR Spectroscopy. In vitro assays were performed with the AECh on murine macrophages J774A.1 cells in order to analyse cell viability, NO, TNF-α and IL-1β productions and the in vivo anti-inflammatory potential in acute carrageenan paw oedema in mice. The AECh showed a decrease in the production of NO, TNF-α and IL-1β, without altering the cell viability and reduction of the paw thickness in the 2nd, 3rd and 4th hour. The extract presented 72% free radical scavenging, 0.60% flavonoid content and showed the presence of gallic acid, caffeic acid and catechin as major constituents. The C. hololeuca bark extract showed important antioxidant and anti-inflammatory activity, emphasizing the industrial and pharmacological potential of this plant.

Funding

Brazilian Research Agencies CAPES, CNPq (460184/2014-8) and FAPEMIG (MPR-00262-16) for financial support. Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de Minas Gerais.

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