Carbamazepine cutaneous adverse reactions and HLA gene variation in the Chinese population: a systematic review and meta-analysis

This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The PRISMA checklist is described in Supplementary Table 1. The literature search strategy is shown in Supplementary Material II.The quality range of all included studies, evaluated by Newcastle–Ottawa scoring, is six to nine (Supplementary Table 2). Egger’s test shows that there is no publication bias (Egger’s test, t = 3.32, p = 0.004, Supplementary Figure 4). The publication bias verification is performed using the clipping method, and the result of clipping method indicates that there were no indications of publication with the Duval’s trim and fill method (no new studies added); the results are robust (Supplementary Figure 4). Sensitivity analysis was conducted on 16 meta-results of HLA-B*15:02 and CBZ-SJS/TEN in Figure 3. The combined effect of 16 meta-results did not change significantly after being excluded from the study one by one (Supplementary Figure 5). The distribution of the funnel diagram was relatively symmetrical (Supplementary Figure 6)