posted on 2020-04-27, 10:42authored byNicola Colacurci, Maria Teresa Schettino, Vincenzo Grimaldi, Francesco Paolo De Luca, Gelsomina Mansueto, Dario Costa, Francesco Cacciatore, Pasquale De Franciscis, Claudio Napoli
The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of nulliparous women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in uteri cells could be a promising therapeutic target.
Funding
This work was supported by research institutional funds from Chair of Gynecology, University of Campania “L. Vanvitelli” (Prof. N. Colacurci) and Immunohistochemistry laboratory of Federico II University of Naples (Dr. G. Mansueto).